SharpyGLP-1 Medications
Plain-English guides to Ozempic, Wegovy, Mounjaro, Zepbound, Saxenda, and the science behind GLP-1 receptor agonists.
- Retatrutide Clinical Trials: Results, Status, How to Join7 minRetatrutide clinical trials explained: every phase 3 TRIUMPH and TRANSCEND study, results so far, which trials are still enrolling, and how to sign up.
- Mounjaro and Birth Control: Does It Make the Pill Less Effective?6 minMounjaro and birth control: the label says tirzepatide can make the pill less effective. When to add backup, which methods are safe, and Zepbound too.
- Zepbound for Sleep Apnea: Approval, AHI Results, Coverage7 minZepbound sleep apnea guide: what the FDA approved, how much AHI dropped in SURMOUNT-OSA, insurance and Medicare criteria, and whether you still need CPAP.
- Foundayo (Orforglipron): Side Effects, Results, and Cost7 minFoundayo (orforglipron) is Lilly's daily GLP-1 pill for weight loss. See the side effects, weight loss results, cost, and how it compares to the Wegovy pill.
- Retatrutide: Side Effects, Results, and FDA Approval Status7 minRetatrutide is Lilly's triple-agonist weight loss shot, still in trials. See the phase 3 results, side effects, FDA timeline, and the black-market risks.
- Wegovy Pill Cost: Self-Pay, Subscription, Insurance, Medicare7 minWegovy pill cost in 2026: $149 to $299 a month self-pay, $249 on a 12-month subscription, $25 with insurance, $50 on Medicare. See every price by dose.
- GLP-1 vs. Peptides: What Is the Difference, and Which Ones Work for Weight Loss?3 minEvery GLP-1 shot is a peptide, but not every peptide is a GLP-1. Here is a plain-English map of approved weight-loss peptides, the ones in trials, and the "research peptides" to avoid.
- Your First 30 Days on GLP-1: A Day-by-Day Survival Guide5 minThe first month on Ozempic, Wegovy, Mounjaro, or Zepbound is the hardest. Here is the day-by-day playbook for managing side effects, hitting protein, and starting strong.
- 15 Questions to Ask Your Doctor When Starting a GLP-15 minMost GLP-1 prescribing visits are 15 minutes long. Here is the printable list of questions that gets you the dose, monitoring, and plan you actually need.
- GLP-1 Medication Comparison: Ozempic vs Wegovy vs Mounjaro vs Zepbound4 minA side-by-side comparison of the major GLP-1 medications: molecule, dosing, cost, FDA indication, side effects, and average weight loss. Pick the right one for your situation.
- Microdosing GLP-1: The Trend, the Reality, and What the Data Shows3 minSome patients use sub-therapeutic GLP-1 doses for "metabolic optimization" or maintenance. Here is what microdosing actually means, who it might help, and what to be skeptical of.
- Rybelsus: The Oral Semaglutide Pill — How It Compares to Injectable3 minRybelsus is oral semaglutide — the same molecule as Ozempic and Wegovy in pill form. Less effective than injectable, but easier to take. Here is what to know.
- GLP-1 Cost and Insurance Coverage: How to Actually Get These Drugs Covered4 minOut-of-pocket costs for GLP-1 medications can run $1,000+ per month. Here is the playbook for insurance coverage, manufacturer programs, and managing prior authorizations.
- GLP-1 Medications and Type 2 Diabetes: How They Lower Blood Sugar3 minGLP-1 drugs were designed to lower blood sugar before they became weight-loss famous. Here's how they work in diabetes, what to expect for HbA1c, and what changes when you also lose weight.
- Compounded GLP-1: What It Is, Why It Exists, and Whether to Trust It3 minCompounded semaglutide and tirzepatide became widely available during shortages. The FDA has tightened rules. Here's how compounding works, the risks, and what to look for.
- Saxenda (Liraglutide): The Daily-Injection GLP-1 That Started It All3 minSaxenda was the first GLP-1 approved for weight loss. It is daily, less effective than semaglutide and tirzepatide, but still has a role for some patients. Here's what you need to know.
- Zepbound vs Mounjaro: When the Same Drug Has Two Brand Names3 minZepbound and Mounjaro are both tirzepatide. The differences are FDA labeling, insurance coverage, and which population they were studied in. Here's the practical breakdown.
- Mounjaro (Tirzepatide): The Dual-Action GLP-1 That Changed the Game3 minMounjaro is tirzepatide — a dual GIP/GLP-1 receptor agonist that consistently outperforms semaglutide in trials. Here's how it works, dosing, side effects, and what to expect.
- Wegovy vs Ozempic: Same Molecule, Different Label — What Actually Differs3 minWegovy and Ozempic are both semaglutide. The differences come down to dose, FDA indication, insurance coverage, and the patient population studied. Here's what you need to know.
- Ozempic for Weight Loss: A Practical Guide for People Who Want to Keep Their Muscle3 minEverything you need to know about Ozempic for weight loss — how semaglutide works, realistic timelines, side effects, dosing, and how to avoid losing muscle while you lose fat.
Lose fat. Not muscle.
One protein number, one 20-minute workout, one score. Every day.