SharpyScience & Research
How GLP-1 receptor agonists work, what the studies actually say, and why "Ozempic muscle loss" is the real story.
- The Major GLP-1 Trials, Summarized: STEP, SURMOUNT, SUSTAIN, SURPASS4 minFive major trial programs underpin everything we know about GLP-1 weight loss. Here is a plain-English summary of what each one showed.
- GLP-1 and Cardiovascular Health: The SELECT Trial and Beyond4 minGLP-1 medications reduce major cardiovascular events independently of weight loss. Here is what the SELECT trial showed and what it means for who should be on these drugs.
- GLP-1 and Bone Density: The Risk No One Talks About4 minRapid weight loss can decrease bone density — especially in postmenopausal women. Here is the science, the risk factors, and the resistance training and supplementation protocol.
- 12 Common Myths About GLP-1 Medications, Debunked4 minFrom "it just makes you sick" to "Ozempic causes cancer" — here are the most common GLP-1 myths and what the actual evidence says.
- GLP-1 and Insulin Resistance: How These Drugs Reverse the Core Problem3 minInsulin resistance is the metabolic foundation of type 2 diabetes and most obesity. Here is how GLP-1 medications attack it from multiple angles.
- GLP-1 for Fatty Liver Disease (NAFLD/MASH): Why It Works3 minNon-alcoholic fatty liver disease (now called MASH) responds dramatically to GLP-1 medications. Here is the mechanism, the data, and what to expect.
- Leptin, Ghrelin, and Why Your Body Fights Weight Loss4 minThe hunger and satiety hormones don't cooperate with weight loss. Here is how leptin and ghrelin work, why they fight regain, and how GLP-1 changes the equation.
- Sarcopenia, Aging, and GLP-1: Why Older Adults Need to Be Especially Careful4 minAge-related muscle loss is the long-term risk factor most amplified by GLP-1 weight loss. Here is what sarcopenia is, why it matters, and the protocol that protects.
- How GLP-1 Affects Your Metabolism (and What "Metabolic Adaptation" Means)4 minWeight loss lowers metabolic rate — that's "metabolic adaptation," and GLP-1 weight loss is no exception. Here is the science and what to do about it.
- What the Research Actually Shows About GLP-1 Rebound Weight Gain4 minStudies of patients stopping GLP-1 medications consistently show significant rebound. Here is what the data actually says, why it happens, and what predicts who keeps the weight off.
- GLP-1 vs GIP: The Two Gut Hormones Behind Modern Weight-Loss Drugs3 minGLP-1 and GIP are the two "incretin" hormones your gut releases after meals. Here's how they differ, why activating both at once is more effective, and what that means for next-generation drugs.
- How GLP-1 Receptor Agonists Actually Work in Your Body3 minGLP-1 medications mimic a gut hormone you already make. Here's the biology of why they suppress appetite, slow digestion, and change blood sugar — without the marketing fluff.
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